Dr. Archana Mal ·
Teeth Regrowing Drug: Trial in Japan
Researchers in Japan are studying an antibody-based approach to tooth development. Here is what the science and current clinical research do—and do not—show.
Why researchers are studying tooth regrowth
The research grew from work by Kyoto University scientists, including oral surgeon Dr Katsu Takahashi, and the biotechnology company Toregem BioPharma. It focuses on USAG-1, a protein involved in tooth development. Researchers are studying whether an antibody that blocks this protein could help activate tooth growth.
Early studies in mice and other animal models helped researchers explore the approach. Animal results are only an early step: they cannot show on their own whether a medicine will be safe or effective in people, or whether a new tooth would develop in the right place and shape.
What the clinical research means
The investigational medicine is known as TRG035. It is being developed first for people born without some permanent teeth, a specific condition called congenital tooth agenesis. This research is not yet an established treatment for everyone who has lost a tooth through decay, injury or gum disease.
In an update dated 17 August 2026, the company reported that Japan’s Pharmaceuticals and Medical Devices Agency had completed its investigation of a clinical-trial notification for a planned Phase IIa study. This is a research milestone, not proof that the medicine is approved, available, or proven to regrow teeth. Clinical studies must continue to assess safety and gather evidence.
Questions researchers still need to answer
Researchers need to learn whether the approach works safely in people and which patients, if any, may benefit. They also need to understand how a new tooth would develop and emerge, and whether the results can be repeated. The answers take time and depend on evidence from carefully reviewed studies.
Early reports sometimes included future target dates, possible prices or plans to expand the treatment to other kinds of tooth loss. These are not guarantees. Research timelines, trial plans and costs can change as new evidence becomes available.
What to do if you have a missing or painful tooth
Tooth-regrowth medicine remains investigational. If you have a missing, damaged or painful tooth, do not delay an assessment while waiting for a possible future treatment. A dentist can examine the area and explain established options, such as a bridge, denture or implant, based on your oral health and needs.
For current research updates, check the study sponsor and participating hospitals. Floss & Gloss does not offer TRG035 or another tooth-regrowth medicine. This article is a general overview, not personal medical advice.
